M3 - Multiscale Muscle Mechanics Lab at UVA









	3D Finite-Element Muscle Modeling We have developed an image-based computational framework for characcterizing the complex three-dimensional architecture and geometry of skeletal muscles (for example, a model of the gluteus maximus muscle is shown on the left). We have gained a number of insights regarding the structure-function relationships of skeletal muscle using 3D muscle models. For example, analyses of 3D models identified the effects of aponeurosis morphology on muscle tissue strains and the effects of complex fiber trajectories on fiber excursions. We are now using these tools to create models of the hamstrings to investigate the mechanisms for strain injury and of the triceps surae muscle to investigate the mechanics of muscle contractures in cerebral palsy.

	Musculoskeletal Modeling Using motion capture technologies and a custom-built instrumented wall, we are studying the biomechanics of rock climbing as part of a multi-institutional project with the goal of developing advanced climbing tools for soldiers. We use digitized motion data in conjuction with state-of-the-art musculoskeletal models of the body to study the interaction between muscle function and human movement.

	Muscle Imaging We are using a variety of imaging techniques to characterize the structure and behavior of muscle in vivo. These measurements provide valuable data to build and validate 3D models of muscle and study muscluloskeletal function. Shown on the left is oblique image of a hamstrings mucle and a corresponding map showing the principal strains (color coding) throughout the muscle during active muscle lengthening.

	Ray Biomechanics and Bio-inspired Design Using computerized tomography (CT) imaging and computational methods we are conducting a multi-species study of ray skeletal architecture to elucidate the form-function relationship between ray skeletal architecture and locomotion. Ultimately, we intend to use the imaging and modeling results to inform the mechanical design of Autonomous Underwater Vehicles (UAVs).

	Modeling Muscle Microstructure We are creating finite-element models that describe the morphology and mechanics of muscle fibers and the extracellular matrix. Our goal is to understand how the micro-scale structure influences the overall function and behavior of muscle.

	Cleft Palate Repair Surgery We are using dynamic MRI in conjunction with our finite-element muscle models to understand the function of the palate muscles during speech and improve the outcomes of cleft palate repairs.

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